Refine your search
Collections
Co-Authors
Year
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All
Khedekar, Sanjay
- Effect of Indian Traditional Medicine:Makaradhwaja on Biochemical Parameters in Streptozotocin Induced Diabetic Albino Rats
Abstract Views :361 |
PDF Views:0
Authors
Affiliations
1 Dept. of RS & BK, SSAM & H, MUHS, Nashik, IN
2 Central Ayurveda Drug Research Institute for Drug Development, Kolkata, IN
3 Dept. of RS & BK, All India Institute of Ayurveda, New Delhi, IN
4 Dean, All India Institute of Ayurveda, New Delhi, IN
1 Dept. of RS & BK, SSAM & H, MUHS, Nashik, IN
2 Central Ayurveda Drug Research Institute for Drug Development, Kolkata, IN
3 Dept. of RS & BK, All India Institute of Ayurveda, New Delhi, IN
4 Dean, All India Institute of Ayurveda, New Delhi, IN
Source
Toxicology International (Formerly Indian Journal of Toxicology), Vol 23, No 1 (2016), Pagination: 33-37Abstract
Use of metallic preparations has raised safety concerns and debate in scientific community for containing considerable levels of heavy metals like lead, mercury and/or arsenic etc. Such controversies have tried to malign the reputation of Ayurveda at global levels. Makaradhwaja, one such metallic preparation is frequently being used in many conditions. But, its safety at the levels of ponderal and biochemical parameters is not reported. Considering this, the present study is planned to evaluate safety effect of Triguna Balijarita Makaradhwaja (TBM) and Shadguna Balijarita Makaradhwaja (SBM) in wistar strain albino rats. TBM and SBM were prepared by following classical guidelines. Animals were divided into four groups. TBM and SBM were administered to rats at the doses of 2.63mg/kg along with Guduchi Ghana and honey for 21 days. Blood samples were collected and animals were sacrificed on 22nd day. Ponderal and biochemical parameters were studied. The results showed insignificant changes in the body weight, Serum creatinine, Cholesterol, Triglyceride and HDL; while SGOT, SGPT and Blood urea were decreased significantly by the treatment of TBM and SBM. The findings of the present study suggests that Makaradhwaja in therapeutic doses along with Honey administered to rats for 21 days does not have appreciable toxicological effects on ponderal and biochemical parameters.Keywords
Makaradhwaja, Mercuric Sulphide, Metallic Preparations, Safety, Toxicity.
References
- Vagbhata. Rasaratansamucchaya. 1st ed. Reprint. New Delhi: Meharchand Lachamandas Publications; 1998.
- Govindas Sen. Bhaishajya Ratnavali: Vajikarana Rogadhi-kara. 1st ed. Reprint, Varanasi: Chaukhamba Prakashan; 2011.
- Sadananda Sharma. Rasa Tarangini: Murcchana Vigyaiyam. 11th ed. New Delhi: Motilal Banarsidas; 2009.
- Prabhakar Chatterji. Rasachikitsa: Makaradhwaja Sevana Vidhi. 1st ed. Varanasi: Chowkhamba Vidya Bhawan; 1956.
- Yadavaji Trikamaji Acharya. Siddhayoga Sangraha. Nagpur: Baidyanth Ayurveda Bhavan ltd; 2006.
- Bhavprakasha. Bhavprakash : Madhu Varga. 3rd ed. Reprint. Delhi: Motilal Banarasidas; 1986.
- Omotayo OE, Siti AS, Mohd W. Honey - A Novel Antidiabetic Agent. Int Journal biological sciences 2012; 8(6):913934.
- Kumar G, Srivastava A, Sharma SK, Gupta YK. Safety evaluation of an Ayurvedic medicine - Arogyavardhini vati on brain, liver and kidney in rats. J Ethnopharmaco 2012;140:151-60
- Vibha D, Anandan EM, Rajesh SM, Muraleedharan TS, Valiathan MS, Mousumi M, Subhash CL. In-vivo effects of traditional ayurvedic formulations in drosophila melanogaster model relate with therapeutic applications. PLoS ONE 2012, 7(5);e37113: 1-14
- Kumar G, Srivastava A, Sharma SK, Gupta YK. Safety evaluation of mercury based Ayurvedic formulation (Sidh Makardhwaj) on brain cerebrum, liver & kidney in rats. Indian J Med Res 2014;139:610-8
- Saper R, Kales SN, Paquin J, Burns MJ, Eisenberg DM, Davis RB, Phillips RS. Heavy Metal Content of Ayurvedic Herbal Medicine Products. JAMA 2004;292:2868-73
- Saper R, Phillips RS, Sehgal A, Khouri N, Davis RB, Paquin J, Thuppil V, Kales SN. Lead, Mercury, and Arsenic in US and Indian Manufactured Ayurvedic Medicines Sold via the Internet. JAMA 2008;300:915-23
- Hore P, Ahmed M, Ehrlich J, Steffen L, Sedlar S. Lead Poisoning in Pregnant Women Who Used Ayurvedic Medications from India - New York City. 2011–2012, Centre for Disease Control and Prevention (Morbidity and Mortality Weekly Report), 61 (33):24, 2012
- Sathe K, Ali U, Ohri A. Acute renal failure secondary to ingestion of ayurvedic medicine containing mercury. Indian J Nephrol 2013; 23:301-3.
- Khedekar S, Patgiri BJ, Ravishankar B, Prajapati PK. Standard manufacturing process of Makaradhwaja prepared by Swarna Patra-Varkha and Bhasma. Ayu 2011;32:109-15.
- Khedekar S, Prajapati P K, Standard Manufacturing process of Shadguna Balijarita Makaradhwaja, Ayu 2014:35; 428-32 17. Sanjay Khedekar, B Ravishankar, PK Prajapati. Role of Gandhaka Jarana in the preparation of Makaradhwaja; (PhD Thesis), IPGT & RA, Gujarat Ayurved University, Jamnagar; 2012
- Akbarzadeh A, Norouzian D, Mehrabi M, Jamshidi S, Farhangi A, Verdi A, Mofidian S, Rad B. Induction of diabetes by Streptozotocin in rats. Indian J Clin Biochem. 2007 Sep; 22(2): 60–64.
- Khedekar S, Patgiri BJ, Ravishankar B, Prajapati PK. Antihyperglycemic effect of makaradhwaja on streptozotacin induced diabetes in rats. J Glob Pharma Tech 2012;4:16-24.
- Charde R, Sharma R, Patgiri BJ, Prajapati PK. Efficacy of Makaradhwaja on Madhumeha (Type2 Diabetes) – A Review through Ayurvedic Studies. Amer J of Phytom Clini Thera 2014; 2(12):1470-79
- Khedekar S, Prajapati P, Patgiri B, Galib R. A scientific review of gold containing herbo-mineral preparation : Makaradhwaja. Green Pharm 2015; 9(4):S7-11.
- Von Berg R, Greenwood MR, editors. 18. Mercury: Metal and their compound in environment. New York: VCH Publisher Inc; 1991. p. 1045-8.
- El-Shenawy SM, Hassan NS. Comparative evaluation of the 19 protective effect of selenium and garlic against liver and kidney damage induced by mercury chloride in the rats. Pharmacol Rep 2008; 60 : 199-208.
- Khedekar S, Galib R, Ravishankar B, Prajapati P. Anti-diabetic activity of traditional Indian gold containing preparation: Shadguna Balijarita Makaradhwaja on streptozotocin induced diabetic rats. J Intercult Ethnopharmacol 2016; 5(2):162-167.
- Ginsberg H. Diabetic dyslipidemia: basic mechanisms underlying the common hypertriglyceridemia and low HDL cholesterol levels. Diabetes 1996,45 suppl 3.S27-30.
- Aurell M, Bjorck S. Determination of progressive renal disease in diabetes mellitus. Kidney Int 1992;41:38–42
- Jefferson LS, Warren SL, Lia O, Daniel E. Peavy, Tho-mas B. Miller, Micheal C.appel, John M. Taylor. Diabetes induced alterations in liver protein synthesis. The J Biological chemistry 1983; 258: 1369-1375
- Abu H, Nair K. Protein metabolism in diabetes mellitus. Baillieres Clin Endocrinol Metabo. 1996; 10(4):589-601.
- Khedekar S, Galib R, Patgiri B, Ravishankar B, Prajapati PK, Antidiabetic activity of dried extract of Tinospora cordifolia (Guduchi Ghana) and honey in streptozotacine induced diabetic rats. Green Pharm 2015; 9(4):S31-37.